3.0 T Magnetic Resonance Functional Imaging Quantitative Parameters for Differential Diagnosis of Benign and Malignant Lesions of the Breast

Xue Cheng; Chunmiao Chen; Haihong Xia; Laxi Zhang; Min Xu

doi:10.1089/cbr.2019.3040

3.0 T Magnetic Resonance Functional Imaging Quantitative Parameters for Differential Diagnosis of Benign and Malignant Lesions of the Breast

Cancer Biother Radiopharm. 2021 Aug;36(6):448-455. doi: 10.1089/cbr.2019.3040. Epub 2020 Jul 23.

Authors

Xue Cheng^{1

2}, Chunmiao Chen^{1

2}, Haihong Xia^{1

2}, Laxi Zhang³, Min Xu^{1

2}

Affiliations

¹ Zhejiang Provincial Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, Lishui Hospital of Zhejiang University, Lishui, China.
² Department of Radiology, Lishui Hospital of Zhejiang University, Lishui, China.
³ Department of Radiology, Jiujiang University Clinical Medical College, Jiujiang University Hospital, Jiujiang, People's Republic of China.

PMID: 32716710
DOI: 10.1089/cbr.2019.3040

Abstract

Objective: To investigate value of quantitative dynamic contrast-enhanced magnetic resonance imaging (MRI) parameters and apparent diffusion coefficient (ADC) value in differential diagnosis of breast benign and malignant lesions, and their correlation with prognostic factors of breast cancer. Methods: The study collected MRI images and clinical data from 232 female patients suspected of breast cancer. Philips INGENIA 3.0T superconducting magnetic resonance scanner was used for imaging examination. Complete pathological data of patients were collected, and the expression of ER, PR, HER-2, and Ki-67 were further investigated. Results: K_ep was higher in malignant breast lesion group than that in benign breast lesion group, and ADC value was lower in the former group than that in the latter group (both p < 0.05). The areas under the receiver operating characteristic curves for K_ep, ADC, and extravascular volume fraction (V_e) were 0.904 (95% confidence interval [CI]: 0.863-0.945), 0.813 (95% CI: 0.752-0.875), and 0.774 (95% CI: 0.707-0.841), respectively. Furthermore, according to the maximum Youden index, the specificity of K_ep and the sensitivity of ADC were high, which were 97.20% and 96.00%, respectively, with a cutoff value of 0.314 and 0.151, respectively. K_ep value in ER-positive expression group was significantly higher than that in ER-negative expression group (p < 0.05). K_ep value in PR-positive expression group was significantly higher than that in PR-negative expression group (p < 0.05). There was positive correlation between K_ep and expression of Ki-67 (p < 0.05). ADC value was negatively correlated with Ki-67 expression (p < 0.05). Conclusion: Quantitative parameters K_ep and ADC of 3.0 T MR functional imaging can be used as reference indexes for differential diagnosis of benign and malignant breast lesions and for biological behavior evaluation, indicating potential clinical value for noninvasive preoperative evaluation of breast cancer.

Keywords: 3.0 T MR functional imaging; ADC; Kep; Ve; breast cancer; differential diagnosis; prognosis.

MeSH terms

Breast Neoplasms / diagnostic imaging*
Diagnosis, Differential
Female
Humans
Magnetic Resonance Imaging / methods*