ent-Atisane diterpenoids: isolation, structure and bioactivity

Grace J Drummond; Phillip S Grant; Margaret A Brimble

doi:10.1039/d0np00039f

ent-Atisane diterpenoids: isolation, structure and bioactivity

Nat Prod Rep. 2021 Mar 4;38(2):330-345. doi: 10.1039/d0np00039f.

Authors

Grace J Drummond¹, Phillip S Grant¹, Margaret A Brimble²

Affiliations

¹ School of Chemical Sciences, The University of Auckland, Symonds Street, Auckland 1010, New Zealand.
² School of Chemical Sciences, The University of Auckland, Symonds Street, Auckland 1010, New Zealand and Maurice Wilkins Centre of Molecular Biodiscovery, The University of Auckland, Symonds Street, Auckland 1010, New Zealand. m.brimble@auckland.ac.nz.

PMID: 32716458
DOI: 10.1039/d0np00039f

Abstract

Covering: up to 2020 ent-Atisane diterpenoids are a class of over 150 members with diverse structures and valuable bioactivities. These compounds share a curious history in which the synthesis of the archetypal member preceded its isolation from natural sources. In this review, we provide a comprehensive summary of the isolation, structure, and bioactivity of ent-atisane diterpenoids from their discovery in 1965 to the present day.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology
Antiviral Agents / chemistry
Antiviral Agents / pharmacology
Diterpenes / chemistry*
Diterpenes / isolation & purification
Diterpenes / metabolism
Diterpenes / pharmacology*
Humans
Molecular Structure
Oxidation-Reduction

Substances

Anti-Bacterial Agents
Antineoplastic Agents
Antiviral Agents
Diterpenes