Si-Miao-Yong-An (SMYA) Decoction May Protect the Renal Function Through Regulating the Autophagy-Mediated Degradation of Ubiquitinated Protein in an Atherosclerosis Model

Ze-Bing Zhu; Ke Song; Wei-Jun Huang; Hui Li; Hui Yang; Yun-Qi Bai; Ke-Ting Guo; Rui-Bing Yang; Wen-Jiao Lou; Chen-Hui Xia; Bo Nie; Wei-Jing Liu

doi:10.3389/fphar.2020.00837

Si-Miao-Yong-An (SMYA) Decoction May Protect the Renal Function Through Regulating the Autophagy-Mediated Degradation of Ubiquitinated Protein in an Atherosclerosis Model

Front Pharmacol. 2020 Jul 2:11:837. doi: 10.3389/fphar.2020.00837. eCollection 2020.

Authors

Ze-Bing Zhu^{1

2}, Ke Song¹, Wei-Jun Huang^{1

2}, Hui Li¹, Hui Yang¹, Yun-Qi Bai¹, Ke-Ting Guo^{1

2}, Rui-Bing Yang^{1

2}, Wen-Jiao Lou^{1

2}, Chen-Hui Xia^{1

2}, Bo Nie¹, Wei-Jing Liu^{1

2}

Affiliations

¹ Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
² Renal Research Institute of Beijing University of Chinese Medicine, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, China.

Abstract

Hyperlipidemia is common, and its renal toxicity has attracted a great deal of attention. Si-miao-yong-an (SMYA) is a famous ancient decoction of traditional Chinese medicine (TCM), which is still widely used in clinical treatment. In this study, we observed and explored its efficacy and mechanism in protecting renal function in an atherosclerosis model. The results showed that the serum, Cr urinal KIM-1, and NGAL were significantly decreased in SMYA group. Although SMYA failed to alleviate the lipid accumulation, decrease p-NFκB, or increase SOD in kidney tissue, the levels of ubiquitinated protein and P62 were decreased in SMYA group. What is more, a higher LC3 II level was observed in the SMYA group. In conclusion, these data indicated that SMYA decoction may protect renal function in hyperlipidemia via regulating the autophagy-mediated degradation of ubiquitinated protein.

Keywords: Si-miao-yong-an; atherosclerosis; autophagy; traditional Chinese medicine; ubiquitinated protein.