Occult Hepatitis B Virus Infection in Immunized Infants Born to Untreated and Tenofovir-Treated Highly Viremic Mothers

Hong-Yuan Hsu; Huey-Ling Chen; Jia-Feng Wu; Yen-Hsuan Ni; Kai-Chi Chang; Cheng-Lun Chiang; Chien-Nan Lee; Lu-Lu Zhao; Ming-Wei Lai; Shu-Chi Mu; Wan-Hsin Wen; Lung-Huang Lin; Mei-Hwei Chang; Taiwan Study Group for the Prevention of Mother-to-Infant Transmission of HBV (PreMIT study)

doi:10.1016/j.cgh.2020.07.041

Occult Hepatitis B Virus Infection in Immunized Infants Born to Untreated and Tenofovir-Treated Highly Viremic Mothers

Clin Gastroenterol Hepatol. 2021 Jul;19(7):1494-1496. doi: 10.1016/j.cgh.2020.07.041. Epub 2020 Jul 23.

Collaborators

Taiwan Study Group for the Prevention of Mother-to-Infant Transmission of HBV (PreMIT study):
Shyu Mk, Hwa Hl, Su Yn, Shih Jc, Chao Kh, Chiu Yc, Liu Cj, Su Th, Chen Ds, Chen Sm, Lin Cc, Lin Py, Yang Wr, Hu Jj, Yang Ck, Chang Yk, Chen Kh, Lin Hh, Lin Yh, Chen Hj, Pan Hs, Lau Bh, Lee Cl, Cheng Pj, Chang Yl, Chiueh Hy, Wang Th, Hsu Jj, Lo Lm, Hsieh Cl, Cheng Sw, Tsai Ms, She Bq, Peng Fs, Lin Yc, Chen Cp, Huang Jp, Yeung Cy

Affiliations

¹ Department of Pediatrics, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan; Department and Graduate Institute of Medical Education and Bioethics, National Taiwan University College of Medicine, Taipei, Taiwan.
² Department of Pediatrics, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan.
³ Department of Obstetrics and Gynecology, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan.
⁴ Department of Pediatrics, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan.
⁵ Division of Pediatric Gastroenterology, Department of Pediatrics, Liver Research Center, Chang Gung Memorial Hospital, Linkou Branch, Taiwan.
⁶ Department of Pediatrics, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
⁷ Department of Pediatrics, Cardinal Tien Hospital, New Taipei City, Taiwan.
⁸ Department of Pediatrics, Cathay General Hospital, Taipei, Taiwan.
⁹ Department of Pediatrics, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan. Electronic address: changmh@ntu.edu.tw.

PMID: 32712392
DOI: 10.1016/j.cgh.2020.07.041

Abstract

Tenofovir disoproxil fumurate (TDF) therapy during late pregnancy in highly viremic mothers can reduce residual overt hepatitis B virus (HBV) infections of their infants that occur despite immunoprophylaxis.¹^,² Occult HBV infection (OBI) has been defined as the presence of HBV DNA in liver or sera in subjects seronegative for hepatitis B surface antigen (HBsAg).³ OBI has been found in varying proportions of immunized infants born to HBsAg-positive mothers.^4-6 We aimed to investigate the impact of maternal TDF therapy during pregnancy on vertically acquired OBI.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

DNA, Viral
Female
Hepatitis B Surface Antigens
Hepatitis B virus* / genetics
Hepatitis B* / prevention & control
Humans
Infant
Infectious Disease Transmission, Vertical / prevention & control
Mothers
Pregnancy
Tenofovir / therapeutic use

Substances

DNA, Viral
Hepatitis B Surface Antigens
Tenofovir