BIOINTMED: integrated biomedical knowledge base with ontologies and clinical trials

Med Biol Eng Comput. 2020 Oct;58(10):2339-2354. doi: 10.1007/s11517-020-02201-0. Epub 2020 Jul 24.

Abstract

Biomedical data are complex and heterogeneous. An ample reliable quantity of data is important for understanding and exploring the domain. The work aims to integrate biomedical data from various heterogeneous sources like dictionaries or corpus and amalgamate them into a uniform format for easier access by the end-user like biologist, pharmacist, and data scientist. The proposed integrated biomedical knowledge base, BIOINTMED, has 11,299, 12,981, 4428, 61,491, 48,663, and 13,146 unique entities for drugs, diseases, targets, genes, biomedical pathways, and adverse events, respectively. The uniform aggregated collection is also explored to study the interaction among these entity pairs. Finally, a complete statistical analysis of the consolidated biomedical entities is provided.

Keywords: Biomedical integrated system; Biomedical knowledge base; Clinical trials; Data integration; Dictionaries.

MeSH terms

  • Biological Ontologies
  • Clinical Trials as Topic*
  • Databases, Chemical
  • Databases, Pharmaceutical
  • Databases, Protein
  • Drug Interactions
  • Drug-Related Side Effects and Adverse Reactions*
  • Humans
  • Knowledge Bases*
  • Models, Statistical
  • Toxicogenetics