A Patient with Cryoglobulinemic Membranoproliferative GN (MPGN) Who Survived COVID-19 Disease: Case Presentation and Current Data of COVID-19 Infection in Dialysis and Transplanted Patients in Greece

Medicina (Kaunas). 2020 Jul 17;56(7):355. doi: 10.3390/medicina56070355.

Abstract

The evolving pandemic of Coronavirus Disease 2019 has posed a substantial health risk worldwide. However, there is a paucity of data regarding the clinical course and the therapeutic management of patients with chronic kidney disease and COVID-19 infection. To date, most evidence has come from renal transplantation, with about 45 patients reported thus far, and the current data from the ERA-EDTA (ERACODA) registry for transplanted patients and patients on Renal Replacement Therapy (RRT); as for those with glomerular diseases, data are lacking. Herein, we report the case of a 62-year-old patient with severe membranoproliferative glomerulonephritis who had been receiving a high burden of immunosuppression until four months before the COVID-19 infection. He developed severe disease with acute respiratory failure requiring mechanical ventilation. After treatment with hydroxychloroquine and azithromycin, despite his low chances, he gradually recovered and survived. To the best of our knowledge, this is one of the few reported patients with glomerulonephritis who had COVID-19 Besides our single case with glomerulonephritis early during the disease outbreak, the very low prevalence of COVID-19 infection in the country's transplant recipients (0.038%) and dialysis patients (0.24%) reflects the impact of the rapid implementation of social distancing rules as well as of preventive measures for disease control in the hospitals and dialysis units in our country.

Keywords: COVID-19; Renal Replacement Therapy (RRT); glomerulonephritis; immunosuppression; pneumonia; transplantation.

Publication types

  • Case Reports

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Azithromycin / therapeutic use
  • Betacoronavirus
  • COVID-19
  • Ceftriaxone / therapeutic use
  • Coronavirus Infections / complications*
  • Coronavirus Infections / diagnosis
  • Coronavirus Infections / immunology
  • Coronavirus Infections / therapy
  • Creatinine / metabolism
  • Cryoglobulinemia / complications*
  • Cryoglobulinemia / immunology
  • Cyclophosphamide
  • Enzyme Inhibitors / therapeutic use
  • Glomerulonephritis, Membranoproliferative / complications*
  • Glomerulonephritis, Membranoproliferative / drug therapy
  • Glomerulonephritis, Membranoproliferative / immunology
  • Glomerulonephritis, Membranoproliferative / metabolism
  • Glucocorticoids / therapeutic use
  • Greece
  • Humans
  • Hydroxychloroquine / therapeutic use
  • Immunocompromised Host
  • Immunologic Factors / therapeutic use
  • Kidney Failure, Chronic / therapy
  • Kidney Transplantation
  • Leukemia, Lymphocytic, Chronic, B-Cell / complications
  • Leukemia, Lymphocytic, Chronic, B-Cell / immunology
  • Lung / diagnostic imaging
  • Male
  • Methylprednisolone / therapeutic use
  • Middle Aged
  • Pandemics
  • Pneumonia, Viral / complications*
  • Pneumonia, Viral / diagnosis
  • Pneumonia, Viral / immunology
  • Pneumonia, Viral / therapy
  • Renal Dialysis
  • Respiration, Artificial
  • Respiratory Insufficiency / etiology*
  • Respiratory Insufficiency / therapy
  • Reverse Transcriptase Polymerase Chain Reaction
  • Rituximab / therapeutic use
  • SARS-CoV-2
  • Tomography, X-Ray Computed

Substances

  • Anti-Bacterial Agents
  • Enzyme Inhibitors
  • Glucocorticoids
  • Immunologic Factors
  • Rituximab
  • Hydroxychloroquine
  • Ceftriaxone
  • Azithromycin
  • Cyclophosphamide
  • Creatinine
  • Methylprednisolone