Prefrontal regulation of behavioural control: Evidence from learning theory and translational approaches in rodents

Abstract

Everyday activities require adaptive decision-making and control over our actions to achieve our goals. Sub-regions within the cortex are widely reported to regulate these choices. Here we review rodent studies from two disparate fields of instrumental action control - goal-directed and habitual responding, and impulsive and compulsive behaviour. Our aim was to compare findings across the spectrum, from precision associative learning to translational studies of action control. The evidence suggests that each cortical sub-region performs different roles depending on task requirements and, within tasks, clear dissociations exist between regions. Rather than synthesizing a single role or function for a given region, we should consider regions to be capable of many different functions. Further investigation of cortico-cortical connections and the pattern of input and output circuitry within each region may be needed to identify unique process-specific pathways. Despite differences in the scope and purpose of these two fields, integrating evidence across tasks provides a broader context for testing hypotheses about the role of cortical regions in adaptive actions and decision-making.

Keywords: Compulsive; Decision-making; Goal-directed; Habit; Impulsive; Instrumental; Insular cortex; Orbitofrontal cortex; Prefrontal cortex; Punishment; Rodent.