Transition-metal-catalyzed C-H functionalization of pyrazoles

Org Biomol Chem. 2020 Aug 19;18(32):6192-6210. doi: 10.1039/d0ob01265c.

Abstract

This review describes recent advances in transition-metal-catalyzed C-H functionalization reactions of pyrazoles to form new C-C and C-heteroatom bonds on the pyrazole ring. In contrast to traditional cross-coupling reactions that require pre-functionalized pyrazoles, direct C-H functionalization reactions provide access to a wide range of functionalized pyrazoles in a single step. Various strategies are presented and the efficiency and regioselectivity are described with respect to the types of functional groups that are installed.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't