NRAS Mutation Detected in a Melanoma With Chondroid Stroma: A Case Report With Molecular Evaluation and Literature Review of a Rare Form of Melanoma

Am J Dermatopathol. 2020 Aug;42(8):608-611. doi: 10.1097/DAD.0000000000001608.

Abstract

Melanoma with cartilaginous differentiation is a rare histologic subtype that has been reported in the literature. It often presents clinically different than conventional melanomas and can be diagnostically challenging. Molecular alterations in previously reported cases have not been published. We present a case of melanoma with chondroid stroma from a 70-year-old man that was found to contain an NRAS mutation (c.182A>G (p.Q61R)) via Illumina TruSight Tumor 15 (TST15) next generation sequencing assay.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adenocarcinoma
  • Aged
  • Carcinoma, Basal Cell
  • GTP Phosphohydrolases / genetics*
  • Humans
  • Male
  • Melanoma / genetics*
  • Melanoma / pathology*
  • Membrane Proteins / genetics*
  • Mutation
  • Neoplasms, Second Primary / genetics
  • Neoplasms, Second Primary / pathology
  • Prostatic Neoplasms
  • Skin Neoplasms / genetics*
  • Skin Neoplasms / pathology*

Substances

  • Membrane Proteins
  • GTP Phosphohydrolases
  • NRAS protein, human