Hair cell regeneration from inner ear progenitors in the mammalian cochlea

Shasha Zhang; Ruiying Qiang; Ying Dong; Yuan Zhang; Yin Chen; Han Zhou; Xia Gao; Renjie Chai

Hair cell regeneration from inner ear progenitors in the mammalian cochlea

Am J Stem Cells. 2020 Jun 15;9(3):25-35. eCollection 2020.

Authors

Shasha Zhang¹, Ruiying Qiang¹, Ying Dong¹, Yuan Zhang¹, Yin Chen², Han Zhou², Xia Gao², Renjie Chai^{1

3

4

5

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Affiliations

¹ Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University Nanjing 210096, China.
² Department of Otolaryngology Head and Neck Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Jiangsu Provincial Key Medical Discipline (Laboratory) Nanjing 210008, China.
³ Co-Innovation Center of Neuroregeneration, Nantong University Nantong 226001, China.
⁴ Institute for Stem Cell and Regeneration, Chinese Academy of Science Beijing, China.
⁵ Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University Nanjing 211189, China.

PMID: 32699655
PMCID: PMC7364385

Abstract

Cochlear hair cells (HCs) are the mechanoreceptors of the auditory system, and because these cells cannot be spontaneously regenerated in adult mammals, hearing loss due to HC damage is permanent. However, cochleae of neonatal mice harbor some progenitor cells that retain limited ability to give rise to new HCs in vivo. Here we review the regulatory factors, signaling pathways, and epigenetic factors that have been reported to play roles in HC regeneration in the neonatal mammalian cochlea.

Keywords: Cochlea; hair cell regeneration; inner ear progenitor; signaling pathway; transcription factor.

Publication types

Review