Resting-state functional MRI of the default mode network in epilepsy

Ofer M Gonen; Patrick Kwan; Terence J O'Brien; Elaine Lui; Patricia M Desmond

doi:10.1016/j.yebeh.2020.107308

Resting-state functional MRI of the default mode network in epilepsy

Epilepsy Behav. 2020 Oct:111:107308. doi: 10.1016/j.yebeh.2020.107308. Epub 2020 Jul 19.

Authors

Ofer M Gonen¹, Patrick Kwan², Terence J O'Brien², Elaine Lui³, Patricia M Desmond³

Affiliations

¹ The Royal Melbourne Hospital, VIC, Australia; The University of Melbourne, VIC, Australia; The Alfred Hospital, VIC, Australia. Electronic address: Ofer.Gonen@mh.org.au.
² The Royal Melbourne Hospital, VIC, Australia; The University of Melbourne, VIC, Australia; The Alfred Hospital, VIC, Australia; Monash University, VIC, Australia.
³ The Royal Melbourne Hospital, VIC, Australia; The University of Melbourne, VIC, Australia.

PMID: 32698105
DOI: 10.1016/j.yebeh.2020.107308

Abstract

The default mode network (DMN) is a major neuronal network that deactivates during goal-directed tasks. Recent advances in neuroimaging have shed light on its structure and function. Alterations in the DMN are increasingly recognized in a range of neurological and psychiatric conditions including epilepsy. This review first describes the current understanding of the DMN in health, normal aging, and disease as it is acquired via resting-state functional magnetic resonance imaging (MRI), before focusing on how it is affected in various types of focal and generalized epilepsy. These findings support the potential use of DMN parameters as future biomarkers in epilepsy research, diagnosis, and management.

Keywords: Default mode network; Epilepsy; Functional connectivity; Resting-state fMRI.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Brain / diagnostic imaging*
Brain / physiopathology
Brain Mapping / methods
Default Mode Network / diagnostic imaging*
Default Mode Network / physiopathology
Epilepsy / diagnostic imaging*
Epilepsy / physiopathology
Female
Humans
Magnetic Resonance Imaging / methods*
Male
Nerve Net / diagnostic imaging
Nerve Net / physiopathology
Rest* / physiology