Talin1 sets the stage for dendritic cell activation

Björn E Clausen

doi:10.1084/jem.20200574

Talin1 sets the stage for dendritic cell activation

J Exp Med. 2020 Aug 3;217(8):e20200574. doi: 10.1084/jem.20200574.

Author

Björn E Clausen¹

Affiliation

¹ Institute for Molecular Medicine and Paul Klein Center for Immune Intervention, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.

Abstract

In this issue of JEM, Lim et al. (https://doi.org/10.1084/jem.20191810) provide exciting new evidence that talin1 plays an essential role in dendritic cell (DC) maturation and activation. Using conditional knockout mice, they demonstrate that talin1 promotes the formation of a preassembled TLR-Myddosome signaling complex in steady-state DCs but not macrophages. This may explain why DCs respond faster and more vigorously to TLR ligand binding than their closely related macrophages.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Cell Differentiation
Dendritic Cells*
Macrophages
Mice
Mice, Knockout
Signal Transduction*