Intron 2 substitution resulted in HLA-DQB1*02:01:01:02 variant in a Kashmiri Brahmin individual from North India

HLA. 2020 Oct;96(4):539-541. doi: 10.1111/tan.14001. Epub 2020 Aug 5.

Authors

Akanksha Sharma¹, Shweta Tyagi¹, Shashi Kapoor Gautam¹, Mohd Abid¹, Uma Kanga¹

Affiliation

¹ Clinical Immunogenetics Laboratory, Centre for Excellence in Molecular Medicine (ICMR), Department of Transplant Immunology and Immunogenetics, All India Institute of Medical Sciences, New Delhi, India.

PMID: 32697026
DOI: 10.1111/tan.14001

Abstract

HLA-DQB1*02:01:01:02 differs from HLA-DQB1*02:01:01:01 by one nucleotide change in intron 2 at position 3949 (G>C).

Keywords: HLA-DQB1; Kashmiri Brahmin; North India; next generation sequencing; novel allele.

© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alleles
Base Sequence
HLA-DQ beta-Chains / genetics
Humans
India
Introns* / genetics

Substances

HLA-DQ beta-Chains
HLA-DQB1 antigen