Recent synthetic strategies toward the synthesis of spirocyclic compounds comprising six-membered carbocyclic/heterocyclic ring systems

Abstract

Spirocyclic compounds fascinate the synthetic chemists due to their privileged ring system and efficacy in drug discovery. Many natural compounds comprise spirocyclic moiety in their skeleton and are effective in pharmaceutical industry. Over the years, many synthetic methodologies have been established for the construction of spirocyclic compounds. In this review, recent synthetic approaches to accessing various spirocompounds comprising six-membered carbocycles/heterocycles have been summarized.

Keywords: Anticancer; Isatin; Michael reaction; Organocatalysts; Spirocarbocycles.