The eminent roles of ncRNAs in the pathogenesis of psoriasis

Soudeh Ghafouri-Fard; Reyhane Eghtedarian; Mohammad Taheri; Azadeh Rakhshan

doi:10.1016/j.ncrna.2020.06.002

The eminent roles of ncRNAs in the pathogenesis of psoriasis

Noncoding RNA Res. 2020 Jul 3;5(3):99-108. doi: 10.1016/j.ncrna.2020.06.002. eCollection 2020 Sep.

Authors

Soudeh Ghafouri-Fard¹, Reyhane Eghtedarian¹, Mohammad Taheri², Azadeh Rakhshan³

Affiliations

¹ Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
² Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
³ Department of Pathology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Abstract

Psoriasis is a chronic immune-related disorder in which both genetic and environmental parameters are involved. Recent studies have demonstrated dysregulation of long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) in the peripheral blood or skin lesions of patients with psoriasis. While a number of lncRNAs such as MEG3, AL162231.4 and NONHSAT044111 have been down-regulated in the course of psoriasis, others including PRINS, MIR31HG, RP6-65G23.1, MSX2P1, SLC6A14-1:1, NR_003062 have been up-regulated. Moreover, expressions of several miRNAs have been dysregulated in this disorder. Among dysregulated miRNAs are miR-126, miR-143, miR-19a and miR-155 whose diagnostic roles in the psoriasis have also been assessed. Dysregulated non-coding RNAs in this disorder participate in the regulation of chemokine signaling pathway and immune response, control of epidermal development and skin barrier as well as modulation of function of certain subsets of T cells. Besides, these transcripts possibly regulate activity of NF-κΒ, mTOR, MAPK and JAK-STAT signaling pathways. Besides, expression levels of circRNAs have been decreased in the psoriasis lesions. Massive alterations in the levels of lncRNAs and miRNAs in the psoriasis lesions or peripheral blood of affected individuals show participation of these transcripts in the pathogenesis of this disorder.

Keywords: Psoriasis; lncRNA; miRNA.

Publication types

Review