Hyper IgM Syndrome Type 2 Presenting as Intestinal Lymphoid Polyposis Without Recurrent Infection

J Investig Allergol Clin Immunol. 2020;30(5):362-364. doi: 10.18176/jiaci.0504. Epub 2020 Jul 21.

Authors

R de la Varga-Martínez¹, M Vilches-Moreno¹, A Viejo-Almanzor², J Pérez-Requena³, C Rodríguez¹, F Mora-López¹

Affiliations

¹ Servicio de Inmunología, UGC de Hematología, Inmunología y Genética, Hospital Universitario Puerta del Mar, Cádiz, Spain.
² UGC de Aparato Digestivo, Hospital Universitario Puerta del Mar, Cádiz, Spain.
³ Servicio de Anatomía Patológica, Hospital Universitario Puerta del Mar, Cádiz, Spain.

PMID: 32694097
DOI: 10.18176/jiaci.0504

No abstract available

Keywords: Activation-induced cytidine deaminase; Benign lymphoid polyposis; Class switch recombination; Hyper IgM syndrome; Immunodeficiency.

Publication types

Case Reports

MeSH terms

Adult
B-Lymphocytes / immunology
B-Lymphocytes / metabolism
Biomarkers
Biopsy
Colonoscopy
Diagnosis, Differential
Disease Susceptibility
Germinal Center / immunology
Germinal Center / metabolism
Germinal Center / pathology
Humans
Hyper-IgM Immunodeficiency Syndrome / diagnosis*
Hyper-IgM Immunodeficiency Syndrome / etiology
Immunoglobulin Class Switching / genetics
Immunoglobulin M / blood
Immunoglobulin M / genetics
Immunoglobulin M / immunology
Immunohistochemistry
Intestinal Polyposis / diagnosis*
Intestinal Polyposis / etiology
Male
Mutation
Peyer's Patches / pathology*
Symptom Assessment

Substances

Biomarkers
Immunoglobulin M