TSH Elicits Cell-Autonomous, Biphasic Responses: A Mechanism Inhibiting Hyperstimulation

Endocrinology. 2020 Aug 1;161(8):bqaa103. doi: 10.1210/endocr/bqaa103.
No abstract available

Keywords: TSH; TSH receptor; cAMP production; inverted U-shaped dose response curve.

Publication types

  • Research Support, N.I.H., Intramural

MeSH terms

  • Animals
  • Cell Physiological Phenomena / drug effects
  • Drug-Related Side Effects and Adverse Reactions / prevention & control
  • Gene Expression Regulation / drug effects
  • Hormesis / drug effects*
  • Humans
  • Receptors, Thyrotropin / agonists
  • Receptors, Thyrotropin / metabolism*
  • Signal Transduction / drug effects
  • Signal Transduction / genetics
  • Thyroid Epithelial Cells / cytology
  • Thyroid Epithelial Cells / drug effects*
  • Thyroid Epithelial Cells / physiology
  • Thyrotropin / pharmacology*

Substances

  • Receptors, Thyrotropin
  • Thyrotropin