Protrudin in protrudinG invadopodia: Membrane contact sites and cell invasion

J Cell Biol. 2020 Aug 3;219(8):e202006146. doi: 10.1083/jcb.202006146.

Abstract

Invadopodia are dynamic protrusions that harbor matrix metalloproteinases for pericellular matrix degradation. However, the mechanisms underlying their maturation are poorly understood. Pedersen et al. (2020. J. Cell Biol.https://doi.org/10.1083/jcb.202003063) demonstrate a dual role of Protrudin in invadopodia elongation and matrix degradation, central to cell invasion and cancer metastasis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Endosomes
  • Exocytosis
  • Extracellular Matrix
  • Matrix Metalloproteinase 14
  • Matrix Metalloproteinases
  • Podosomes*

Substances

  • Matrix Metalloproteinases
  • Matrix Metalloproteinase 14