Direct N-formylation of nitroarenes with CO2

Ni Shen; Shi-Jing Zhai; Chi Wai Cheung; Jun-An Ma

doi:10.1039/d0cc03098h

Direct N-formylation of nitroarenes with CO₂

Chem Commun (Camb). 2020 Aug 28;56(67):9620-9623. doi: 10.1039/d0cc03098h. Epub 2020 Jul 21.

Authors

Ni Shen¹, Shi-Jing Zhai, Chi Wai Cheung, Jun-An Ma

Affiliation

¹ Department of Chemistry, Tianjin Key Laboratory of Molecular Optoelectronic Sciences, Frontiers Science Center for Synthetic Biology (Ministry of Education), and Tianjin Collaborative Innovation Centre of Chemical Science & Engineering, Tianjin University, Tianjin 300072, P. R. of China. zhiwei.zhang@tju.edu.cn majun_an68@tju.edu.cn.

PMID: 32691036
DOI: 10.1039/d0cc03098h

Abstract

Herein we describe a straightforward N-formylation of nitroarenes with CO₂ to access N-aryl formamides exclusively in the presence of iron and hydrosilane as additives. This protocol showcases a good tolerance of a wide range of nitroarenes and nitroheteroarenes.