lncRNA ZEB2-AS1: A promising biomarker in human cancers

IUBMB Life. 2020 Sep;72(9):1891-1899. doi: 10.1002/iub.2338. Epub 2020 Jul 20.

Abstract

Long non-coding RNAs (lncRNAs) are one of the ncRNAs that transcript with length more than 200 nt that are not translated into protein. Studies have shown that lncRNAs have regulatory function in human disease especially cancers. lncRNA dysfunction causes altered cellular behavior including proliferation, invasion, and migration, and also it can inhibit apoptosis. Long non-coding zinc finger E-box binding homeobox 2 antisense RNA1 (lnZEB2-AS1) is one of the lncRNAs that plays the oncogenic role in different cancers. Dysregulation of lncZEB2-AS1 can lead to tumorigenesis and cancer progression. lncZEB2-AS1 may be introduced as a diagnostic marker or therapeutic target for human cancers. In this review, we describe briefly the mechanism of ZEB2-AS1 in cells and its function in cancer progression.

Keywords: TGFβ; biomarker; cancer; lncRNA ZEB2-AS1; non-coding RNA.

Publication types

  • Review

MeSH terms

  • Apoptosis
  • Cell Proliferation
  • Epithelial-Mesenchymal Transition
  • Humans
  • Neoplasms / diagnosis*
  • Neoplasms / genetics
  • RNA, Antisense / genetics*
  • RNA, Long Noncoding / genetics*
  • Zinc Finger E-box Binding Homeobox 2 / genetics*

Substances

  • RNA, Antisense
  • RNA, Long Noncoding
  • ZEB2 protein, human
  • Zinc Finger E-box Binding Homeobox 2