Antimicrobial-resistant Mycoplasma genitalium is becoming increasingly common and creating major treatment challenges. We present early data on combination therapy with doxycycline and sitafloxacin to treat highly resistant M. genitalium. We found the regimen was well tolerated and cured 11/12 infections that had failed prior regimens with moxifloxacin and pristinamycin.
Keywords: AMR; Mycoplasma genitalium; antimicrobial resistance; doxycycline; dual-class resistance; macrolide resistance; multidrug resistance; quinolone resistance; sexually transmitted infections; sitafloxacin.