Chagas disease is emerging in countries to which it is not endemic. Biomarkers for earlier therapeutic response assessment in patients with chronic Chagas disease are needed. We profiled plasma-derived extracellular vesicles from a heart transplant patient with chronic Chagas disease and showed the potential of this approach for discovering such biomarkers.
Keywords: Bolivia; Chagas disease; Plasma; Spain; Trypanosoma cruzi; biomarkers; extracellular vesicles; heart transplantation; parasites; proteomic analysis; tropical diseases.