Ploidy Leads a Molecular Motor to Walk Different Paths to Drug Resistance

Alexander M Real; William M Marsiglia; Arvin C Dar

doi:10.1016/j.chembiol.2020.06.019

Ploidy Leads a Molecular Motor to Walk Different Paths to Drug Resistance

Cell Chem Biol. 2020 Jul 16;27(7):770-772. doi: 10.1016/j.chembiol.2020.06.019.

Authors

Alexander M Real¹, William M Marsiglia¹, Arvin C Dar²

Affiliations

¹ Department of Oncological Sciences, Department of Pharmacological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
² Department of Oncological Sciences, Department of Pharmacological Sciences, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: arvin.dar@mssm.edu.

Abstract

In this issue of Cell Chemical Biology, Pisa et al. (2020) find that haploid and diploid cells differentially develop resistance to the CENP-E inhibitor GSK923295. The results highlight the power of tumor cells to evade growth inhibition and potentially inform the design of next-generation CENP-E drugs to overcome resistance.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Bridged Bicyclo Compounds, Heterocyclic
Diploidy*
Drug Resistance
Haploidy
Humans
Neoplasms*

Substances

Bridged Bicyclo Compounds, Heterocyclic

Abstract

Publication types

MeSH terms

Substances

Grants and funding