The Effects of YAP and Its Related Mechanisms in Central Nervous System Diseases

Jiayan Jin; Xiaoxuan Zhao; Huifang Fu; Yuan Gao

doi:10.3389/fnins.2020.00595

The Effects of YAP and Its Related Mechanisms in Central Nervous System Diseases

Front Neurosci. 2020 Jun 26:14:595. doi: 10.3389/fnins.2020.00595. eCollection 2020.

Authors

Jiayan Jin^{1

2}, Xiaoxuan Zhao^{1

2}, Huifang Fu^{1

3}, Yuan Gao^{4

1

5}

Affiliations

¹ Department of Forensic Science, School of Basic Medical Science, Wenzhou Medical University, Wenzhou, China.
² School of the 2nd Clinical Medical Sciences, Wenzhou Medical University, Wenzhou, China.
³ Department of Pathology, Traditional Chinese Medicine Hospital of Jiangning District, Nanjing, China.
⁴ Department of Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Academy of Forensic Science, Shanghai, China.
⁵ Forensic Center, Wenzhou Medical University, Wenzhou, China.

Abstract

Yes-associated protein (YAP) is a key effector downstream of the Hippo signaling pathway and plays an important role in the development of the physiology and pathology of the central nervous system (CNS), especially regulating cell proliferation, differentiation, migration, and apoptosis. However, the roles and underlying mechanisms of YAP in CNS diseases are still puzzling. Here, this review will systematically and comprehensively summarize the biological feature, pathological role, and underlying mechanisms of YAP in normal and pathologic CNS, which aims to provide insights into the potential molecular targets and new therapeutic strategies for CNS diseases.

Keywords: Hippo signaling pathway; YAP; central nervous system diseases; effect; mechanism.

Publication types

Review