Antifouling molecularly imprinted membranes for pretreatment of milk samples: Selective separation and detection of lincomycin

Zeqing Dong; Jian Lu; Yilin Wu; Minjia Meng; Chao Yu; Chang Sun; Muning Chen; Zulin Da; Yongsheng Yan

doi:10.1016/j.foodchem.2020.127477

Antifouling molecularly imprinted membranes for pretreatment of milk samples: Selective separation and detection of lincomycin

Food Chem. 2020 Dec 15:333:127477. doi: 10.1016/j.foodchem.2020.127477. Epub 2020 Jul 10.

Authors

Zeqing Dong¹, Jian Lu¹, Yilin Wu¹, Minjia Meng¹, Chao Yu², Chang Sun³, Muning Chen¹, Zulin Da⁴, Yongsheng Yan⁵

Affiliations

¹ Institute of Green Chemistry and Chemical Technology, School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China.
² School of Environmental and Safety Engineering, Jiangsu University, Zhenjiang 212013, China.
³ College of Computer Science and Technology, Beihua University, Jilin 132013, China.
⁴ Institute of Green Chemistry and Chemical Technology, School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China. Electronic address: dazulin@ujs.edu.cn.
⁵ Institute of Green Chemistry and Chemical Technology, School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China. Electronic address: yys@mail.ujs.edu.cn.

PMID: 32673956
DOI: 10.1016/j.foodchem.2020.127477

Abstract

As a veterinary antibiotic, lincomycin (LIN) residues in milk are raising concerns of public on account of potential harm to human health. Efficient strategy is eagerly desired for detection of LIN from milk samples. Hence, lincomycin molecularly imprinted membranes (LINMIMs) were developed for selective separation of LIN as an efficient pretreatment of milk samples. The synergistic effect of polyethylenimine and dopamine provided effective antifouling performance by improving the hydrophilicity. Based on click chemistry, specific recognition sites were facilely formed on membranes using 4-vinylpyridine as functional monomers. The satisfactory rebinding capacity (151.62 mg g^-1), permselectivity (4.43), together with the linear dependence (R² = 0.9902) of concentrations in eluents and original samples. Moreover, the method was utilized to determine LIN from milk, with good recovery and relative standard deviation. Achievements in this work will actively promote the development of efficient detection technology.

Keywords: Antifouling; Lincomycin; Milk; Molecularly imprinted membrane; Selective detection.

MeSH terms

Animals
Biofouling / prevention & control*
Drug Residues / analysis
Drug Residues / isolation & purification
Food Contamination / analysis*
Lincomycin / analysis*
Lincomycin / isolation & purification*
Membranes, Artificial*
Milk / chemistry*
Molecular Imprinting*

Substances

Membranes, Artificial
Lincomycin