Effects of Renin-Angiotensin Inhibition on ACE2 (Angiotensin-Converting Enzyme 2) and TMPRSS2 (Transmembrane Protease Serine 2) Expression: Insights Into COVID-19

Hypertension. 2020 Oct;76(4):e29-e30. doi: 10.1161/HYPERTENSIONAHA.120.15782. Epub 2020 Jul 14.

Authors

Congqing Wu¹, Dien Ye¹, Adam E Mullick¹, Zhenyu Li¹, A H Jan Danser¹, Alan Daugherty¹, Hong S Lu¹

Affiliation

¹ From the Saha Cardiovascular Research Center (C.W., D.Y., Z.L., A.D., H.S.L.), Department of Internal Medicine (C.W., Z.L.), and Department of Physiology (A.D., H.S.L.), University of Kentucky, Lexington, Kentucky; Erasmus MC, Rotterdam, the Netherlands (D.Y., A.H.J.D.); and Ionis Pharmaceuticals, Inc, Carlsbad, CA (A.E.M.).

No abstract available

Publication types

Letter
Research Support, N.I.H., Extramural

MeSH terms

Angiotensin II Type 2 Receptor Blockers / pharmacology
Angiotensin-Converting Enzyme 2
Angiotensin-Converting Enzyme Inhibitors / pharmacology
Animals
Betacoronavirus / physiology*
COVID-19
Coronavirus Infections* / metabolism
Coronavirus Infections* / virology
Enalapril / pharmacology*
Losartan / pharmacology*
Male
Mice
Mice, Inbred C57BL
Pandemics*
Peptidyl-Dipeptidase A* / genetics
Peptidyl-Dipeptidase A* / metabolism
Pneumonia, Viral* / metabolism
Pneumonia, Viral* / virology
RNA, Messenger / analysis
SARS-CoV-2
Serine Endopeptidases* / genetics
Serine Endopeptidases* / metabolism
Tissue Distribution

Substances

Angiotensin II Type 2 Receptor Blockers
Angiotensin-Converting Enzyme Inhibitors
RNA, Messenger
Enalapril
Peptidyl-Dipeptidase A
Ace2 protein, mouse
Angiotensin-Converting Enzyme 2
Serine Endopeptidases
TMPRSS2 protein, mouse
Losartan

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