Current status of micro/nanomotors in drug delivery

J Drug Target. 2021 Jan;29(1):29-45. doi: 10.1080/1061186X.2020.1797052. Epub 2020 Aug 6.

Abstract

Synthetic micro/nanomotors (MNMs) are novel, self-propelled nano or microscale devices that are widely used in drug transport, cell stimulation and isolation, bio-imaging, diagnostic and monitoring, sensing, photocatalysis and environmental remediation. Various preparation methods and propulsion mechanisms make MNMs "tailormade" nanosystems for the intended purpose or use. As the one of the newest members of nano carriers, MNMs open a new perspective especially for rapid drug transport and gene delivery. Although there exists limited number of in-vivo studies for drug delivery purposes, existence of in-vitro supportive data strongly encourages researchers to move on in this field and benefit from the manoeuvre capability of these novel systems. In this article, we reviewed the preparation and propulsion mechanisms of nanomotors in various fields with special attention to drug delivery systems.

Keywords: Micro/nanomotor; biodegradation; drug delivery; nanotechnology; propulsion.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Drug Delivery Systems / methods*
  • Drug Delivery Systems / trends
  • Humans
  • Microspheres*
  • Nanostructures / administration & dosage*
  • Nanostructures / chemistry
  • Nanotechnology / methods*
  • Nanotechnology / trends
  • Pharmaceutical Preparations / administration & dosage*
  • Pharmaceutical Preparations / chemistry

Substances

  • Pharmaceutical Preparations