Drug Development and Treatment of Autophagy in Other Diseases

Adv Exp Med Biol. 2020:1207:689-697. doi: 10.1007/978-981-15-4272-5_51.

Abstract

In addition to tumors and aging that are associated with autophagy, many other diseases are also regulated by autophagy, including liver disease, myopathy, immune pathogen infection, cardiovascular disease, and so on. This chapter will detail the relationship between autophagy and these diseases and their underlying molecular mechanisms. We summarized the current research status of autophagy as a target for the treatment of related diseases, and prospected the development of related drugs and therapeutic strategies. We hope to provide new ideas for finding new therapeutic targets through the autophagic signaling pathways.

Keywords: Autophagy; Cardiovascular disease; Immune pathogen infection; Liver disease; Myopathy.

Publication types

  • Review

MeSH terms

  • Autophagy / drug effects*
  • Cardiovascular Diseases / drug therapy*
  • Drug Development*
  • Humans
  • Infections / drug therapy*
  • Liver Diseases / drug therapy*
  • Muscular Diseases / drug therapy*
  • Signal Transduction / drug effects