Chemotherapy is an important means of treating malignant tumours. The main role of chemotherapy drugs is to induce cell death. However, the apoptotic pathways of many tumour cells are often severely impaired, leading to failure of chemotherapy-induced apoptosis. With the in-depth study of autophagy in recent years, this process has been found to play an important role in the chemoresistance of tumours. Autophagy may have different effects on tumour cells depending on the specific environment. In addition, tumour stem cells and the tumour microenvironment are closely related to tumour recurrence and metastasis. It is also important to study the role of autophagy in tumour stem cells and the microenvironment to investigate chemotherapy resistance.
Keywords: Autophagy; Chemoresistance; Tumour microenvironment; Tumour stem cells.