Abstract
Two water-soluble amphiphilic Ru(ii) polypyridyl complexes containing N-1,10-phenanthrolin-5-yldocosanamide and 1,10-phenanthroline (phen) or 1,4,5,8-tetraazaphenanthrene (TAP) as ligands were synthesised and their photophysical and photobiological properties evaluated; both complexes showed a rapid cellular uptake and displayed phototoxicity against HeLa cervical cancer cells.
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Cell Survival / drug effects
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Coordination Complexes / chemistry
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Coordination Complexes / pharmacology*
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HeLa Cells
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Humans
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Ligands
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Optical Imaging
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Pyridines / chemistry
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Pyridines / pharmacology
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Reactive Oxygen Species / metabolism
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Ruthenium / chemistry
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Ruthenium / pharmacology
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Solubility
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Surface-Active Agents / chemistry
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Surface-Active Agents / pharmacology*
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Water / chemistry
Substances
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Antineoplastic Agents
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Coordination Complexes
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Ligands
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Pyridines
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Reactive Oxygen Species
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Surface-Active Agents
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Water
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Ruthenium