Obesity preventive function of novel edible mushroom, Basidiomycetes-X (Echigoshirayukidake): Manipulations of insulin resistance and lipid metabolism

Mst Afifa Khatun; Shinji Sato; Tetsuya Konishi

doi:10.1016/j.jtcme.2020.03.004

Obesity preventive function of novel edible mushroom, Basidiomycetes-X (Echigoshirayukidake): Manipulations of insulin resistance and lipid metabolism

J Tradit Complement Med. 2020 Apr 8;10(3):245-251. doi: 10.1016/j.jtcme.2020.03.004. eCollection 2020 May.

Authors

Mst Afifa Khatun^{1

2}, Shinji Sato¹, Tetsuya Konishi^{1

3}

Affiliations

¹ Faculty of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences, 265-1 Higashijima, Akiha-ku, Niigata, 956-8603, Japan.
² Food Safety and Quality Analysis Division, Institute of Food and Radiation Biology, Atomic Energy Research Establishment, Savar, Dhaka, 1000, Bangladesh.
³ Office HALD Food Function Research, Yuzawa, Minami-Uonuma City, Niigata, 949-6103, Japan.

Abstract

Echigoshirayukidake is an edible mushroom found in Uonuma, Japan in 1994. It was assigned to a new species of Basidiomycetes (BDM-X) but is uniquely defect of forming bashidium. The high antioxidant activity and β-glucan content of BDM-X suggest possible functions preventing type 2 diabetes. In the present study, anti-obesity and insulin resistance preventive functions of BDM-X were examined using genetically defined obese model rat, OLETF (Otsuka Long Evans Tokushima Fatty) by feeding regular diet with and without supplementation of 5% dried BDM-X powder (BDMP) for 15 weeks. BDMP supplementation to the diet significantly (p < 0.01) suppressed the body weight gain and also visceral fat accumulation during the feeding period compared to control diet. Simultaneously, the insulin resistance and the plasma levels of adiponectin and triglycerides were significantly (p = 0.003) ameliorated in the BDMP supplemented diet group. A statistical multivariate analysis showed the weight of three types of adipose tissue (epididymal, retroperirenal, and mesenteric fat) positively correlated with HOMA-IR (Homeostasis Model Assessment of Insulin Resistance), and negatively correlated with plasma adiponectin. These results indicate BDM-X is a new resource applicable to the functional foods or the complementary biomedicines to prevent metabolic syndromes leading to type 2 diabetes.

Keywords: Adiponectin; BDM-X, Basidiomycetes-X; BDMP, BDM-X powder; Echigoshirayukidake (BDM-X); HOMA-IR, Homeostasis Model Assessment of Insulin Resistance; Insulin resistance; LETO, Long-Evans Tokushima Otsuka rat; NEFA, Non-Esterified Free fatty Acid; OGTT, Oral Glucose Tolerance Test; OLETF, Otsuka Long Evans Tokushima Fatty rat; Obesity; Type 2 diabetes.