The Association of Extreme Tachycardia and Sustained Return of Spontaneous Circulation after Nontraumatic Out-of-Hospital Cardiac Arrest

Dong Keon Lee; Eugi Jung; You Hwan Jo; Joonghee Kim; Jae Hyuk Lee; Seung Min Park; Yu Jin Kim

doi:10.1155/2020/5285178

The Association of Extreme Tachycardia and Sustained Return of Spontaneous Circulation after Nontraumatic Out-of-Hospital Cardiac Arrest

Emerg Med Int. 2020 Jun 29:2020:5285178. doi: 10.1155/2020/5285178. eCollection 2020.

Authors

Dong Keon Lee¹, Eugi Jung², You Hwan Jo^{1

3}, Joonghee Kim¹, Jae Hyuk Lee¹, Seung Min Park¹, Yu Jin Kim¹

Affiliations

¹ Department of Emergency Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
² Department of Emergency Medicine, VHS Medical Center, Seoul, Republic of Korea.
³ Department of Emergency Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.

Abstract

Objective: Heart rate (HR), an essential vital sign that reflects hemodynamic stability, is influenced by myocardial oxygen demand, coronary blood flow, and myocardial performance. HR at the time of the return of spontaneous circulation (ROSC) could be influenced by the β1-adrenergic effect of the epinephrine administered during cardiopulmonary resuscitation (CPR), and its effect could be decreased in patients who have the failing heart. We aimed to investigate the association between HR at the time of ROSC and the outcomes of adult out-of-hospital cardiac arrest (OHCA) patients.

Methods: This study was a secondary analysis of a cardiac arrest registry from a single institution from January 2008 to July 2014. The OHCA patients who achieved ROSC at the emergency department (ED) were included, and HR was retrieved from an electrocardiogram or vital sign at the time of ROSC. The patients were categorized into four groups according to the HR (bradycardia (HR < 60), normal HR (60 ≤ HR ≤ 100), tachycardia (100 < HR < 150), and extreme tachycardia (HR ≥ 150)). The primary outcome was the rate of sustained ROSC and the secondary outcomes were the rate of one-month survival and six-month good neurologic outcome.

Results: A total of 330 patients were included. In the univariate logistic regression model, the rate of sustained ROSC increased by 17% as HR increased by every 10 beats per minute (bpm) (odds ratio (OR), 1.171; 95% confidence interval (CI), 1.077-1.274, p < 0.001). In the multivariate logistic regression model, extreme tachycardia was independently associated with a high probability of sustained ROSC compared to normal heart rate (OR, 15.96; 95% CI, 2.04-124.93, p=0.008).

Conclusion: Extreme tachycardia (HR ≥ 150) at the time of ROSC is independently associated with a high probability of sustained ROSC in nontraumatic adult OHCA patients.