Ethical challenges for pediatric liver organoid transplantation

Sarah A Schneemann; Sarah N Boers; Johannes J M van Delden; Edward E S Nieuwenhuis; Sabine A Fuchs; Annelien L Bredenoord

doi:10.1126/scitranslmed.aau8471

Ethical challenges for pediatric liver organoid transplantation

Sci Transl Med. 2020 Jul 15;12(552):eaau8471. doi: 10.1126/scitranslmed.aau8471.

Authors

Sarah A Schneemann^{1

2}, Sarah N Boers¹, Johannes J M van Delden¹, Edward E S Nieuwenhuis^{2

3}, Sabine A Fuchs⁴, Annelien L Bredenoord⁵

Affiliations

¹ Julius Center for Health Sciences and Primary Care, Department of Medical Humanities, University Medical Center Utrecht, 3508 GA, Utrecht, Netherlands.
² Department of Pediatrics, Wilhelmina Children's Hospital, University Medical Center Utrecht, 3508 AB, Utrecht, Netherlands.
³ Science Department, University College Roosevelt, Middelburg, Netherlands.
⁴ Department of Metabolic Diseases, Wilhelmina Children's Hospital, University Medical Center Utrecht, 3508 AB, Utrecht, Netherlands. s.fuchs@umcutrecht.nl a.l.bredenoord@umcutrecht.nl.
⁵ Julius Center for Health Sciences and Primary Care, Department of Medical Humanities, University Medical Center Utrecht, 3508 GA, Utrecht, Netherlands. s.fuchs@umcutrecht.nl a.l.bredenoord@umcutrecht.nl.

PMID: 32669425
DOI: 10.1126/scitranslmed.aau8471

Abstract

Liver organoid transplantation may be a less invasive alternative to liver transplant, but is it ethically acceptable to include children with liver disease in a first-in-human clinical trial of this new intervention?

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Child
Humans
Liver Diseases*
Liver Transplantation*
Organoids