The extracellular matrix and mechanotransduction in pulmonary fibrosis

Zhenjun Deng; Mark W Fear; Yu Suk Choi; Fiona M Wood; Amira Allahham; Steven E Mutsaers; Cecilia M Prêle

doi:10.1016/j.biocel.2020.105802

The extracellular matrix and mechanotransduction in pulmonary fibrosis

Int J Biochem Cell Biol. 2020 Sep:126:105802. doi: 10.1016/j.biocel.2020.105802. Epub 2020 Jul 12.

Authors

Zhenjun Deng¹, Mark W Fear², Yu Suk Choi³, Fiona M Wood⁴, Amira Allahham¹, Steven E Mutsaers⁵, Cecilia M Prêle⁶

Affiliations

¹ Burn Injury Research Unit, School of Biomedical Sciences, The University of Western Australia, Nedlands, 6009, WA, Australia.
² Burn Injury Research Unit, School of Biomedical Sciences, The University of Western Australia, Nedlands, 6009, WA, Australia; Institute for Respiratory Health, Nedlands, WA, Australia.
³ School of Human Sciences, The University of Western Australia, Crawley, WA, Australia.
⁴ Burn Injury Research Unit, School of Biomedical Sciences, The University of Western Australia, Nedlands, 6009, WA, Australia; Burns Service of Western Australia, Perth Children's Hospital, Nedlands, WA, Australia; Fiona Stanley Hospital, Murdoch, WA, Australia.
⁵ Institute for Respiratory Health, Nedlands, WA, Australia; Centre for Respiratory Health, School of Biomedical Sciences, The University of Western Australia, Nedlands, WA, Australia; Centre for Cell Therapy and Regenerative Medicine, School of Biomedical Sciences, The University of Western Australia, Nedlands, WA, Australia.
⁶ Institute for Respiratory Health, Nedlands, WA, Australia; Centre for Respiratory Health, School of Biomedical Sciences, The University of Western Australia, Nedlands, WA, Australia; Centre for Cell Therapy and Regenerative Medicine, School of Biomedical Sciences, The University of Western Australia, Nedlands, WA, Australia. Electronic address: cecilia.prele@uwa.edu.au.

PMID: 32668329
DOI: 10.1016/j.biocel.2020.105802

Abstract

Pulmonary fibrosis is characterised by excessive scarring in the lung which leads to compromised lung function, serious breathing problems and in some diseases, death. It includes several lung disorders with idiopathic pulmonary fibrosis (IPF) the most common and most severe. Pulmonary fibrosis is considered to be perpetuated by aberrant wound healing which leads to fibroblast accumulation, differentiation and activation, and deposition of excessive amounts of extracellular matrix (ECM) components, in particular, collagen. Recent studies have identified the importance of changes in the composition and structure of lung ECM during the development of pulmonary fibrosis and the interaction between ECM and lung cells. There is strong evidence that increased matrix stiffness induces changes in cell function including proliferation, migration, differentiation and activation. Understanding how changes in the ECM microenvironment influence cell behaviour during fibrogenesis, and the mechanisms regulating these changes, will provide insight for developing new treatments.

Keywords: Collagen; Extracellular matrix; Mechanotransduction; Pulmonary fibrosis; Signal transduction.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Collagen / metabolism
Extracellular Matrix / metabolism*
Humans
Mechanotransduction, Cellular*
Pulmonary Fibrosis / metabolism
Pulmonary Fibrosis / pathology*

Substances

Collagen