The clinicopathologic diagnosis and treatment of a case of endometrial verrucous carcinoma were analyzed, combined with the relevant literature for review and discussion. The patient was a 67-year-old postmenopausal woman who had recurrent vaginal bleeding with increased secretion. The gross morphology and histopathology of the uterine cavity tumor had typical characteristic changes of verrucous carcinoma. There was obvious inflammation in the tumor background and squamous differentiation in the residual endometrial gland basal reserve cells. Tumor cell immunohistochemistry showed wild-type P53, P16 negative expression and HPV molecular test was negative. The expression of p63 was positive in squamous differentiated reserve cells, and Ki67 showed high proliferative activity. Verrucous carcinoma of endometrium is a rare tumor with low malignancy, that belongs to a special subtype of squamous cell carcinoma. It is easily missed or misdiagnosed and has a long diagnosis cycle. The diagnosis should be combined with clinical data, imaging and pathology. The pathogenesis of the disease is not clear. Surgical treatment is the first treatment, and the clinical prognosis is good.
Keywords: Endometrium; non-HPV-related; reserve cells; verrucous carcinoma.
IJCEP Copyright © 2020.