Is the Reason of Increased D-Dimer Levels in COVID-19 Because of ACE-2-Induced Apoptosis in Endothelium?

Clin Appl Thromb Hemost. 2020 Jan-Dec:26:1076029620935526. doi: 10.1177/1076029620935526.

Authors

Nil Guler¹, Fakiha Siddiqui², Jawed Fareed³

Affiliations

¹ Department of Hematology, Medical School, Pamukkale University, Denizli, Turkey.
² Department of Pathology, Cardiovascular Research Institute, Loyola University Chicago, Health Sciences Division, Maywood, IL, USA.
³ Department of Pathology and Laboratory Medicine, Department of Pharmacology and Neuroscience, Cardiovascular Research Institute, Loyola University Chicago, Health Sciences Division, Maywood, IL, USA.

No abstract available

Publication types

Letter

MeSH terms

Alphacoronavirus / pathogenicity
Angiotensin II / pharmacology
Angiotensin-Converting Enzyme 2
Animals
Apoptosis* / drug effects
Betacoronavirus / pathogenicity*
Betacoronavirus / physiology
COVID-19
Caspase Inhibitors / pharmacology
Caspase Inhibitors / therapeutic use
Chikungunya virus / pathogenicity
Coronavirus Infections / blood
Coronavirus Infections / complications*
Coronavirus Infections / pathology
Coronavirus Infections / virology
Endothelium, Vascular / enzymology
Endothelium, Vascular / pathology
Endothelium, Vascular / virology*
Fibrin Fibrinogen Degradation Products / metabolism*
Host-Pathogen Interactions*
Humans
Models, Cardiovascular
Orthomyxoviridae / pathogenicity
Pandemics
Peptidyl-Dipeptidase A / physiology*
Pneumonia, Viral / blood
Pneumonia, Viral / complications*
Pneumonia, Viral / pathology
Pneumonia, Viral / virology
Receptors, Virus / physiology*
SARS-CoV-2
Swine
Thrombophilia / blood
Thrombophilia / etiology*
Virus Replication
Zika Virus / pathogenicity

Substances

Caspase Inhibitors
Fibrin Fibrinogen Degradation Products
Receptors, Virus
fibrin fragment D
Angiotensin II
Peptidyl-Dipeptidase A
ACE2 protein, human
Angiotensin-Converting Enzyme 2

Supplementary concepts

Swine acute diarrhea syndrome coronavirus