Outer-membrane permeability to beta-lactam antibiotics in Yersinia enterocolitica

K Brzostek; J Hrebenda

doi:10.1099/00221287-134-6-1535

Outer-membrane permeability to beta-lactam antibiotics in Yersinia enterocolitica

J Gen Microbiol. 1988 Jun;134(6):1535-40. doi: 10.1099/00221287-134-6-1535.

Authors

K Brzostek¹, J Hrebenda

Affiliation

¹ Institute of Microbiology, Warsaw University, Poland.

PMID: 3265428
DOI: 10.1099/00221287-134-6-1535

Abstract

Two outer-membrane (OM) proteins of Yersinia enterocolitica YOMP-C and YOMP-F appear to function as porins. Mutants that were YOMP-C- and YOMP-F- exhibited changes in cephaloridine and [3H]glucose uptake and increased resistance to beta-lactam antibiotics (especially cephalosporins) and tetracycline. Alterations in OM permeability may contribute to antibiotic resistance in Yersinia.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / metabolism*
Bacterial Outer Membrane Proteins / metabolism*
Cell Membrane Permeability
Cephalosporins / metabolism
Drug Resistance, Microbial
Mutation
Tetracycline Resistance
Yersinia enterocolitica / metabolism*
beta-Lactamases / metabolism

Substances

Anti-Bacterial Agents
Bacterial Outer Membrane Proteins
Cephalosporins
beta-Lactamases