A topical naltrexone formulation for surgical wound healing: A case report

J Cosmet Dermatol. 2021 Mar;20(3):838-841. doi: 10.1111/jocd.13604. Epub 2020 Jul 24.

Abstract

Background: In current guidelines, there is no specific therapeutic recommendation for promoting surgical wound healing. Proper postsurgical wound care regimen can speed up wound healing and prevent abnormal scarring.

Aims: The purpose of this case study was to evaluate the effectiveness of a compounded topical formulation containing naltrexone in managing surgical wound in a patient after Mohs micrographic surgery (MMS).

Patients/methods: A patient started to apply the topical naltrexone formulation two days after the MMS on his hand. Images of the wound and a Patient Scar Assessment Questionnaire (PSAQ) were used to evaluate the clinical outcomes.

Results: The wound completely healed, and the hand function was fully recovered following application of the formulation for 2 weeks. No abnormal scarring was formed, and the scar was only slightly noticeable after 2 months.

Conclusion: This case study demonstrated the effectiveness of the topical naltrexone formulation in surgical wound management.

Keywords: Mohs surgery; topical naltrexone; wound healing.

Publication types

  • Case Reports

MeSH terms

  • Administration, Topical
  • Cicatrix
  • Humans
  • Mohs Surgery
  • Naltrexone* / therapeutic use
  • Surgical Wound*
  • Wound Healing

Substances

  • Naltrexone