Non-congenital viral infections of the central nervous system: from the immunocompetent to the immunocompromised child

Pediatr Radiol. 2020 Nov;50(12):1757-1767. doi: 10.1007/s00247-020-04746-6. Epub 2020 Jul 10.

Abstract

Non-congenital viral infections of the central nervous system in children can represent a severe clinical condition that needs a prompt diagnosis and management. However, the aetiological diagnosis can be challenging because symptoms are often nonspecific and cerebrospinal fluid analysis is not always diagnostic. In this context, neuroimaging represents a helpful tool, even though radiologic patterns sometimes overlap. The purpose of this pictorial essay is to suggest a schematic representation of different radiologic patterns of non-congenital viral encephalomyelitis based on the predominant viral tropism and vulnerability of specific regions: cortical grey matter, deep grey matter, white matter, brainstem, cerebellum and spine.

Keywords: Central nervous system; Children; Encephalitis; Magnetic resonance imaging; Myelitis; Viral infection; Viral tropism.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Brain / diagnostic imaging
  • Brain / immunology
  • Brain / virology
  • Child
  • Child, Preschool
  • Encephalitis, Viral / diagnostic imaging*
  • Encephalitis, Viral / immunology*
  • Female
  • Humans
  • Immunocompetence / immunology*
  • Immunocompromised Host / immunology*
  • Infant
  • Infant, Newborn
  • Magnetic Resonance Imaging / methods*
  • Male