Finely tuned Prussian blue-based nanoparticles and their application in disease treatment

Yong Gao; Guocan Yu; Kuoran Xing; Dmitry Gorin; Yuri Kotelevtsev; Weijun Tong; Zhengwei Mao

doi:10.1039/d0tb01248c

Finely tuned Prussian blue-based nanoparticles and their application in disease treatment

J Mater Chem B. 2020 Aug 19;8(32):7121-7134. doi: 10.1039/d0tb01248c.

Authors

Yong Gao¹, Guocan Yu², Kuoran Xing¹, Dmitry Gorin³, Yuri Kotelevtsev⁴, Weijun Tong¹, Zhengwei Mao¹

Affiliations

¹ MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Zheda Road 38, Hangzhou 310027, China. tongwj@zju.edu.cn zwmao@zju.edu.cn.
² Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, USA.
³ Center for Photonics and Quantum Materials, Skolkovo Institute of Science and Technology, Russian Federation.
⁴ Functional Genomics and RNAi Therapy CREI, Skolkovo Institute for Science and Technology, 3 Nobel Street, Skolkovo Moscow region, 143026, Russian Federation.

PMID: 32648878
DOI: 10.1039/d0tb01248c

Abstract

The Prussian blue (PB) based nanostructure is a mixed-valence coordination network with excellent biosafety, remarkable photothermal effect and multiple enzyme-mimicking behaviours. Compared with other nanomaterials, PB-based nanoparticles (NPs) exhibit several unparalleled advantages in biomedical applications. This review begins with the chemical composition and physicochemical properties of PB-based NPs. The tuning strategies of PB-based NPs and their biomedical properties are systemically demonstrated. Afterwards, the biomedical applications of PB-based NPs are comprehensively recounted, mainly focusing on treatment of tumors, bacterial infection and inflammatory diseases. Finally, the challenges and future prospects of PB-based NPs and their application in disease treatment are discussed.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Anti-Bacterial Agents / chemistry*
Anti-Bacterial Agents / pharmacology
Anti-Inflammatory Agents / chemistry*
Anti-Inflammatory Agents / pharmacology
Antineoplastic Agents / chemistry*
Antineoplastic Agents / pharmacology
Biocompatible Materials / chemistry*
Biocompatible Materials / pharmacology
Ferrocyanides / chemistry*
Ferrocyanides / pharmacology
Humans
Magnetic Resonance Imaging
Metal Nanoparticles / chemistry*
Multimodal Imaging
Nanocomposites / chemistry
Optical Imaging
Phototherapy
Polylysine / chemistry
Polyvinyls / chemistry
Porosity
Pyrrolidines / chemistry
Theranostic Nanomedicine

Substances

Anti-Bacterial Agents
Anti-Inflammatory Agents
Antineoplastic Agents
Biocompatible Materials
Ferrocyanides
Polyvinyls
Pyrrolidines
poly(N-vinylpyrrolidine)
Polylysine
ferric ferrocyanide