Towards Design of Self-Organizing Biomimetic Systems

Abstract

The ability of designing biosynthetic systems with well-defined functional biomodules from scratch is an ambitious and revolutionary goal to deliver innovative, engineered solutions to future challenges in biotechnology and process systems engineering. In this work, several key challenges including modularization, functional biomodule identification, and assembly are discussed. In addition, an in silico protocell modeling approach is presented as a foundation for a computational model-based toolkit for rational analysis and modular design of biomimetic systems.

Keywords: bottom-up synthetic biology; functional biomodules; model-based bioengineering; protocell; whole cell model.