Soulieoside U, a new cycloartane triterpene glycoside from Actaea vaginata

Haifeng Wu; Qinwen Yang; Xiangyuan Li; Yindi Zhu; Zhengqi Dong; Guoxu Ma; Xudong Xu; Gui Chen; Xiaokang Ai; Qiongyu Zou; Xing Hu; Xianjin Wu

doi:10.1080/14786419.2020.1789985

Soulieoside U, a new cycloartane triterpene glycoside from Actaea vaginata

Nat Prod Res. 2022 Jan;36(2):560-565. doi: 10.1080/14786419.2020.1789985. Epub 2020 Jul 9.

Authors

Haifeng Wu^{1

2}, Qinwen Yang², Xiangyuan Li², Yindi Zhu³, Zhengqi Dong², Guoxu Ma², Xudong Xu², Gui Chen¹, Xiaokang Ai¹, Qiongyu Zou¹, Xing Hu¹, Xianjin Wu¹

Affiliations

¹ Key Laboratory of Research and Utilization of Ethnomedicinal Plant Resources of Hunan Province and Key Laboratory of Hunan Higher Education for Western Hunan Medicinal Plant and Ethnobotany, Huaihua University, Huaihua 418008, China.
² Beijing Key Laboratory of New Drug Discovery based on Classic Chinese Medicine Prescription, Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China.
³ School of Pharmacy, Wenzhou Medical University, Wenzhou 325035, China.

PMID: 32643409
DOI: 10.1080/14786419.2020.1789985

Abstract

One new cycloartane triterpene bisdesmoside, soulieoside U, was isolated from the rhizomes of Actaea vaginata. Its structure was elucidated by extensive analysis of the NMR and MS data. Soulieoside U was evaluated for cytotoxic activities against three human cancer cell lines.

Keywords: Actaea vaginata; cycloartane triterpene; cytotoxicity.

MeSH terms

Actaea*
Glycosides / pharmacology
Humans
Molecular Structure
Rhizome
Triterpenes* / pharmacology

Substances

Glycosides
Triterpenes
cycloartane