Structure elucidation and NMR assignment of two new hydroxywilfordate-type alkaloids from the stems of Tripterygium hypoglaucum and activity evaluation

Magn Reson Chem. 2020 Oct;58(10):969-974. doi: 10.1002/mrc.5074. Epub 2020 Jul 22.

Authors

Li-He Lu^{1

2

3}, De-Song Wu^{1

2

3}, Yu-Feng Zha^{1

2

3}, Shuang-Xi Mei^{1

2

3}, Xiao-Hui Li^{1

2

3}

Affiliations

¹ Yunnan Institute of Materia Medica, Kunming, 650111, China.
² Innovation and R&D Center, Yunnan Bai Yao Group, Kunming, 650111, China.
³ Yunnan Province Company Key Laboratory for TCM and Ethnic Drug of New Drug Creation, Kunming, 650111, China.

PMID: 32643204
DOI: 10.1002/mrc.5074

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Alkaloids / chemistry
Alkaloids / isolation & purification
Alkaloids / pharmacology*
Animals
Anti-Inflammatory Agents
Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / isolation & purification
Antineoplastic Agents, Phytogenic / pharmacology*
Cell Proliferation / drug effects
Cell Survival / drug effects
Drug Screening Assays, Antitumor
Drugs, Chinese Herbal / chemistry
Drugs, Chinese Herbal / isolation & purification
Drugs, Chinese Herbal / pharmacology*
Hydroxybutyrates / chemistry
Hydroxybutyrates / isolation & purification
Hydroxybutyrates / pharmacology*
Magnetic Resonance Spectroscopy
Mice
Molecular Conformation
Niacin / analogs & derivatives*
Niacin / chemistry
Niacin / isolation & purification
Niacin / pharmacology
RAW 264.7 Cells
Tripterygium / chemistry*

Substances

Alkaloids
Anti-Inflammatory Agents
Antineoplastic Agents, Phytogenic
Drugs, Chinese Herbal
Hydroxybutyrates
hydroxy wilfordic acid
Niacin

Grants and funding

2016DC030/Key Technology Research And International Registration of Zhongtong Aerosol