The production of a high spatial resolution (HR) hyperspectral image (HSI) through the fusion of a low spatial resolution (LR) HSI with an HR multispectral image (MSI) has underpinned much of the recent progress in HSI super-resolution. The premise of these signs of progress is that both the degeneration from the HR HSI to LR HSI in the spatial domain and the degeneration from the HR HSI to HR MSI in the spectral domain are assumed to be known in advance. However, such a premise is difficult to achieve in practice. To address this problem, we propose to incorporate degeneration estimation into HSI super-resolution and present an unsupervised deep framework for "blind" HSIs super-resolution where the degenerations in both domains are unknown. In this framework, we model the latent HR HSI and the unknown degenerations with deep network structures to regularize them instead of using handcrafted (or shallow) priors. Specifically, we generate the latent HR HSI with an image-specific generator network and structure the degenerations in spatial and spectral domains through a convolution layer and a fully connected layer, respectively. By doing this, the proposed framework can be formulated as an end-to-end deep network learning problem, which is purely supervised by those two input images (i.e., LR HSI and HR MSI) and can be effectively solved by the backpropagation algorithm. Experiments on both natural scene and remote sensing HSI data sets show the superior performance of the proposed method in coping with unknown degeneration either in the spatial domain, spectral domain, or even both of them.