Pharmacotranscriptomics of peptide drugs with neuroprotective properties

Lyudmila V Dergunova; Ivan B Filippenkov; Svetlana A Limborska; Nikolai F Myasoedov

doi:10.1002/med.21704

Pharmacotranscriptomics of peptide drugs with neuroprotective properties

Med Res Rev. 2021 Mar;41(2):754-769. doi: 10.1002/med.21704. Epub 2020 Jul 8.

Authors

Lyudmila V Dergunova¹, Ivan B Filippenkov¹, Svetlana A Limborska¹, Nikolai F Myasoedov²

Affiliations

¹ Department of Molecular Bases of Human Genetics, Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia.
² Department of Chemistry of Physiologically Active Compounds, Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia.

PMID: 32638434
DOI: 10.1002/med.21704

Abstract

Here we present a review of studies on the effects of peptides with neuroprotective properties on gene transcription in nerve cells. The few published works in this area clearly demonstrate massive changes in cell transcriptomes induced by peptides under normal conditions and under conditions of experimental brain ischemia. These changes significantly affect signaling and metabolic pathways, affecting various body systems and confirming the multiple target actions of peptides. The importance of noncoding RNAs in the regulation of these processes is shown, and we discuss the prospects of research for determining the main mechanisms of peptide regulation, which is necessary for the further development of drugs with targeted neuroprotective effects.

Keywords: brain ischemia; circular RNA; mRNA; microRNA; noncoding RNA; peptide drugs; pharmacotranscriptomics; regulatory peptides.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

MicroRNAs*
Neuroprotection
Peptides
Pharmaceutical Preparations*
RNA, Circular

Substances

MicroRNAs
Peptides
Pharmaceutical Preparations
RNA, Circular