Magnetic Resonance Diffusion Kurtosis Imaging versus Diffusion-Weighted Imaging in Evaluating the Pathological Grade of Hepatocellular Carcinoma

Guang-Zhi Wang; Ling-Fei Guo; Gui-Hua Gao; Yao Li; Xi-Zhen Wang; Zhen-Guo Yuan

doi:10.2147/CMAR.S254371

Magnetic Resonance Diffusion Kurtosis Imaging versus Diffusion-Weighted Imaging in Evaluating the Pathological Grade of Hepatocellular Carcinoma

Cancer Manag Res. 2020 Jun 29:12:5147-5158. doi: 10.2147/CMAR.S254371. eCollection 2020.

Authors

Guang-Zhi Wang^{1

2}, Ling-Fei Guo³, Gui-Hua Gao³, Yao Li⁴, Xi-Zhen Wang², Zhen-Guo Yuan^{1

3}

Affiliations

¹ Cheeloo College of Medicine, Shandong University, Jinan 250021, People's Republic of China.
² Department of Medical Imaging Center, Affiliated Hospital, Weifang Medical University, Weifang 261053, People's Republic of China.
³ Department of MRI, Shandong Medical Imaging Research Institute, Cheeloo College of Medicine, Shandong University, Jinan 250021, People's Republic of China.
⁴ Zhucheng People's Hospital Affiliated to Weifang Medical University, Weifang 262200, People's Republic of China.

Abstract

Purpose: To investigate the diagnostic efficacy of diffusion kurtosis imaging (DKI) and conventional diffusion-weighted imaging (DWI) for pathological grading.

Methods: From December 2015 to January 2017, consecutive patients suspected of having hepatocellular carcinoma (HCC) without prior treatment were prospectively enrolled in this study. MRI examinations were performed before surgical treatment. HCC patients confirmed by surgical pathology were included in the study. The mean diffusivity (MD) values, mean kurtosis (MK) values, and apparent diffusion coefficient (ADC) were calculated. The differences and correlations of these parameters among different pathological grades were analyzed. The diagnostic efficiency of DKI and DWI for predicting high-grade HCC was evaluated by receiver operating characteristic (ROC) curves. Logistic regression analyses were used to evaluate the predictive factors for pathological grade.

Results: A total of 128 patients (79 males and 49 females, age: 56.9±10.9 years, range, 32-80) with primary HCC were included: grade I: 22 (17.2%) patients, grade II: 37 (28.9%) patients, grade III: 43 (33.6%) patients, grade IV: 26 (20.3%) patients. The MK values of stage I, II, III, and IV were 0.86±0.13, 1.06±0.11, 1.27±0.17, and 1.57±0.13, respectively. The MK values were significantly higher in the high-grade group than in the low-grade group and were positively correlated with pathological grade (rho =0.7417, P<0.001). The MK value demonstrated a larger area under the curve (AUC), with a value of 0.93 than the MD value, which had an AUC of 0.815 (P<0.001), and ADC, which had an AUC of 0.662 (P=0.01). The MK value (>1.19), ADC (≤1.29×10^-3 mm²/s), and HBV (+) were independent predictors for the pathological grade of HCCs.

Conclusion: The MK values derived from DKI and the ADC values obtained from traditional DWI were more valuable than the MD values in predicting the histological grade of HCCs and could potentially guide clinical treatment before surgery.

Keywords: diffusion kurtosis imaging; diffusion-weighted imaging; hepatocellular carcinoma; pathology; predictor.

Grants and funding

This study was supported by grants from Shandong Province Science and Technology Development Project [grant number 2012YD18064], Project of Medicine and Health Development Plan of Shandong Province [grant number 2011HW067], Shandong Provincial Natural Science Foundation [grant number ZR2013HM071], and Key Research and Development Program of Shandong Province [grant number GG2018GSF118171].