Associations between Maternal and Fetal Levels of Total Adiponectin, High Molecular Weight Adiponectin, Selected Somatomedins, and Birth Weight of Infants of Smoking and Non-Smoking Mothers

Magdalena Chełchowska; Joanna Gajewska; Tomasz M Maciejewski; Joanna Mazur; Mariusz Ołtarzewski; Jadwiga Ambroszkiewicz

doi:10.3390/ijerph17134781

Associations between Maternal and Fetal Levels of Total Adiponectin, High Molecular Weight Adiponectin, Selected Somatomedins, and Birth Weight of Infants of Smoking and Non-Smoking Mothers

Int J Environ Res Public Health. 2020 Jul 3;17(13):4781. doi: 10.3390/ijerph17134781.

Authors

Magdalena Chełchowska¹, Joanna Gajewska¹, Tomasz M Maciejewski², Joanna Mazur³, Mariusz Ołtarzewski¹, Jadwiga Ambroszkiewicz¹

Affiliations

¹ Department of Screening Tests and Metabolic Diagnostics, Institute of Mother and Child, Kasprzaka 17a, 01-211 Warsaw, Poland.
² Clinic of Obstetrics and Gynaecology, Institute of Mother and Child, Kasprzaka 17a, 01-211 Warsaw, Poland.
³ Department of Humanization in Medicine and Sexology, Collegium Medicum University of Zielona Góra and Institute of Mother and Child in Warsaw, 65-729 Zielona Góra, Poland.

Abstract

The aim of the study was to determine the relationships between maternal smoking, total adiponectin, high molecular weight adiponectin (HMW adiponectin), selected somatomedins, and the birth weight of newborns. A total of 78 women with a healthy, singleton pregnancy, 41 active smokers and 37 non-smokers, and their offspring were studied. Total and HMW adiponectin, insulin-like growth factor I (IGF-I), and insulin-like growth factor binding protein-1 (IGFBP-1) and 2 (IGFBP-2) were determined in maternal and cord blood by enzyme-link immunosorbent assay. Serum levels of total and HMW adiponectin were lower in smokers compared to the tobacco abstinent in both the mothers (p = 0.013; p = 0.006) and the infants (p = 0.001; p = 0.047). In smoking women and their children, serum concentrations of IGF-I were significantly lower (p = 0.014; p = 0.042), IGFBP-1 significantly higher (p = 0.009; p = 0.039), and IGFBP-2 did not differ from that observed in the non-smoking group. In multivariate analysis performed on the whole group of mothers, the highest impact of serum cotinine and IGFBP-2 levels were indicated for adiponectin and cotinine and the number of cigarettes/day for HMW adiponectin concentration. In correlation analysis estimated separately for smokers and non-smokers, neonatal birth weight was positively associated with total and HMW adiponectin concentrations in umbilical cord blood. Birth weight was also inversely associated with IGFBP-1 and positively correlated with IGF-I levels in maternal serum as well as in cord blood (r = -0.317, p = 0.005; r = -0.294, p = 0.004; r = 0.245, p = 0.031; r = 0.271, p = 0.009, respectively). The present study showed the levels of total and HMW adiponectin in umbilical cord blood may have a significant effect on fetal development. Both IGF-I and IGFBP-1 concentrations also play an essential role in fetal growth, which is an important predictor of birth weight. Cigarette smoking during pregnancy negatively affected adiponectin and the insulin growth factor profile in the serum of women and the cord blood and may be the reason for the lower birth weight of the smokers newborns compared with the nonsmokers offspring.

Keywords: birth weight; cord blood; high molecular weight adiponectin; insulin-like growth factor binding protein-1; pregnancy; tobacco smoke.

MeSH terms

Adiponectin / metabolism*
Birth Weight*
Child
Female
Fetal Blood
Humans
Infant
Infant, Newborn
Insulin-Like Growth Factor I
Male
Molecular Weight
Mothers
Pregnancy
Prenatal Care

Substances

Adiponectin
Insulin-Like Growth Factor I