The role of circular RNAs in hematological malignancies

Zhi Lin; Fei Long; Mingyi Zhao; Xueyan Zhang; Minghua Yang

doi:10.1016/j.ygeno.2020.06.051

The role of circular RNAs in hematological malignancies

Genomics. 2020 Nov;112(6):4000-4008. doi: 10.1016/j.ygeno.2020.06.051. Epub 2020 Jul 4.

Authors

Zhi Lin¹, Fei Long², Mingyi Zhao³, Xueyan Zhang³, Minghua Yang⁴

Affiliations

¹ Department of Pediatrics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.
² Department of Gastrointestinal Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.
³ Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.
⁴ Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China. Electronic address: yangminghua@csu.edu.cn.

PMID: 32634468
DOI: 10.1016/j.ygeno.2020.06.051

Abstract

Circular RNAs (circRNAs) are a class of noncoding RNAs (ncRNAs) that lack a 5' end cap or a 3' end poly-(A) tail and form a circular structure through covalent bonds. Compared to linear RNAs, circRNAs are more conservative and stable, and their distribution is spatiotemporally regulated. circRNAs, as a new type of competitive endogenous RNA (ceRNA), are involved in many disease processes and are also related to the occurrence and development of tumors. Over the past three years, the role of circRNAs in hematological malignancies has received increasing attention. Related research has shown that circRNAs may regulate the occurrence and development of hematological malignancies and contribute to drug resistance through a variety of molecular mechanisms. Therefore, to lay the foundation and point out directions for further research on circRNAs, this article systematically reviews the research progress on circRNAs in leukemia, lymphoma, and myeloma.

Keywords: Leukemia; Lymphoma; Myeloma; ceRNA; circRNAs.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Hematologic Neoplasms / physiopathology*
Humans
RNA, Circular / physiology*

Substances

RNA, Circular