Airway Delivery of Bone Marrow-Derived Mesenchymal Stem Cells Reverses Bronchopulmonary Dysplasia Superimposed with Acute Respiratory Distress Syndrome in an Infant

Hsin-Chia Lin; Ching-Chia Wang; Heng-Wen Chou; En-Ting Wu; Frank Leigh Lu; Bor-Sheng Ko; Ming Yao; Po-Yuan Wang; Mei-Hwan Wu; Yih-Sharng Chen

doi:10.1177/2155179018759434

Airway Delivery of Bone Marrow-Derived Mesenchymal Stem Cells Reverses Bronchopulmonary Dysplasia Superimposed with Acute Respiratory Distress Syndrome in an Infant

Cell Med. 2018 Jun 18:10:2155179018759434. doi: 10.1177/2155179018759434. eCollection 2018.

Authors

Affiliations

¹ Department of Pediatrics, National Taiwan University Hospital Yunlin Branch, Douliu, Yunlin, Taiwan.
² Department of Pulmonology and Critical Care Medicine, National Taiwan University Children's Hospital, Taipei, Taiwan.
³ Division of Cardiovascular Surgery, Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan.
⁴ Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
⁵ Department of General Pediatrics, National Taiwan University Children's Hospital, Taipei, Taiwan.
⁶ Department of Cardiology, National Taiwan University Children's Hospital, Taipei, Taiwan.

Abstract

Bronchopulmonary dysplasia (BPD), a disease affecting extremely premature infants, results from the disruption of normal pulmonary vascular and alveolar growth. Currently, there is no specific effective treatment. We report a case of a 10-mo-old female infant with BPD, who was admitted because of adenovirus pneumonia and acute respiratory distress syndrome (ARDS) with prolonged venovenous and arteriovenous extracorporeal membrane oxygenation (ECMO) support (total 125 d). The respiratory condition dramatically improved, and ECMO was removed 25 d after intratracheal delivery of maternal bone marrow-derived mesenchymal stem cells (BM-MSCs). Short tandem repeat examinations revealed that there was no maternal cells in the bronchial wash fluid. To our knowledge, this is the first human report of BM-MSC therapy reversal of the course of BPD superimposed with ARDS. We also suggest that BM-MSC therapy may not only be effective in the newborn stage but also works in infants and children with BPD.

Keywords: acute respiratory distress syndrome; bronchopulmonary dysplasia; extracorporeal membrane oxygenation; mesenchymal stem cell.

Publication types

Case Reports