Rational design of water-dispersible and biocompatible nanoprobes with H2S-triggered NIR emission for cancer cell imaging

Hengyan Liu; Ge Xu; Tianli Zhu; Rongchen Wang; Jiahui Tan; Chunchang Zhao; Xianfeng Gu

doi:10.1039/d0tb00173b

Rational design of water-dispersible and biocompatible nanoprobes with H₂S-triggered NIR emission for cancer cell imaging

J Mater Chem B. 2020 Jul 28;8(28):6013-6016. doi: 10.1039/d0tb00173b. Epub 2020 Jul 7.

Authors

Hengyan Liu¹, Ge Xu, Tianli Zhu, Rongchen Wang, Jiahui Tan, Chunchang Zhao, Xianfeng Gu

Affiliation

¹ Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, P. R. China. zhaocchang@ecust.edu.cn.

PMID: 32633308
DOI: 10.1039/d0tb00173b

Abstract

We present an approach for constructing a H₂S-specific nanoprobe by the entrapment of a small molecule probe within the hydrophobic interior of surface cross-linked micelles (SCMs), endowing the designed nanoprobes with good water solubility and biocompatibility. Importantly, the obtained nanoprobes displayed good responsiveness to H₂S in both ratiometric fluorescence and light-up NIR emission modes, thus enabling accurate identification of H₂S-rich colorectal cancer cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biocompatible Materials / chemical synthesis
Biocompatible Materials / chemistry*
Colorectal Neoplasms / diagnostic imaging*
Fluorescent Dyes / chemical synthesis
Fluorescent Dyes / chemistry*
HCT116 Cells
Humans
Hydrogen Sulfide / analysis*
Micelles
Nanoparticles / chemistry*
Optical Imaging*
Particle Size
Surface Properties
Water / chemistry

Substances

Biocompatible Materials
Fluorescent Dyes
Micelles
Water
Hydrogen Sulfide